Profluent

Biotechnology · Emeryville, CA · Founded 2022 · Privately Held (backing)

Developer of artificial intelligence-driven models designed to create and validate novel proteins for biomedicine. Profluent is based in Emeryville, CA and was founded in 2022. It was valued at $525 million at its early-stage round in Nov 2025, the last priced event on record. It has raised $150 million across 2 recorded rounds; the latest was a $106 million Series B in Nov 2025.

PMV mark · valuation
$525.0M
Oct 2026
Priced at
its early-stage round
Nov 2025
Total raised
$150.0M
Last round
Early Stage VC (Series B)
Nov 2025
What is Profluent worth?
$525.0MPrivateMarketView mark · Oct 2026

Valued at $525.0M at its early-stage round, Nov 2025. Nothing has traded since.

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Valuation timeline

0 priced rounds · 32 daily marks since · Sep 2026 – Oct 2026
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Markrounds hold their value until the next priced eventMark, today
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Profluent funding history

2 rounds
DateRoundRaisedPost-money
Nov 2025Early Stage VC (Series B)$106.0M▮
Mar 2024Early Stage VC$35.0M▮
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Profluent valuation

Profluent was valued at $525 million at its early-stage round in Nov 2025. That is the last priced event on record: no secondary trade or institutional fund mark has moved the figure since.

How much has Profluent raised?

Profluent has raised $150 million across 2 recorded rounds since 2024. The largest was a $35 million early-stage round in Mar 2024; the most recent was a $106 million Series B in Nov 2025.

Comparable companies

Comparable biotechnology names by valuation on PrivateMarketView: DNA Script ($660 million), Odyssey Therapeutics ($638 million) and bit.bio ($546 million).

How Profluent's valuation is determined

Private company valuations aren’t quoted on an exchange — they’re established in moments: a priced funding round sets a post-money valuation, secondary trades print at a price per share, and SEC-registered funds holding the stock report fair-value marks in their N-PORT filings.

For Profluent, the most current credible signal sets the number and the older ones confirm it: a live secondary-market price first, then three or more recent prints, then institutional fund marks, and otherwise the last priced round, which never decays. The valuation is the last round’s post-money moved by the price change since that round, so no share count is assumed. Today it is set by its last priced round. Question about this number? Full methodology →

Frequently asked about Profluent

What is Profluent worth?
Profluent is valued at $525.0M as of Oct 2026. Valued at $525.0M at its early-stage round, Nov 2025. Nothing has traded since.
How much has Profluent raised?
Profluent has raised $150.0M in total funding across 2 recorded rounds.
When did Profluent last raise?
Profluent last raised in Nov 2025 (Early Stage VC (Series B)), raising $106.0M.