Profluent

Biotechnology · Emeryville, CA · Founded 2022 · Privately Held (backing)

Developer of artificial intelligence-driven models designed to create and validate novel proteins for biomedicine. Profluent is based in Emeryville, CA and was founded in 2022. It was valued at $525 million at its early-stage round in Nov 2025, the last priced event on record. It has raised $150 million across 2 recorded rounds; the latest was a $106 million Series B in Nov 2025.

PMV mark · valuation
$525.0M
Oct 2026
Priced at
its early-stage round
Nov 2025
Total raised
$150.0M
Last round
Early Stage VC (Series B)
Nov 2025
How much has Profluent raised?
$150.0Macross 2 recorded rounds · Mar 2024 – Nov 2025

Most recently, Profluent raised $106.0M in its Early Stage VC (Series B) (Nov 2025).

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Profluent round by round

2 rounds
Nov 2025Early Stage VC (Series B)$106.0M▮
+ 1 more investors · free account
Mar 2024Early Stage VC$35.0M▮
+ 1 more investors · free account

How much has Profluent raised?

Profluent has raised $150 million across 2 recorded rounds since 2024. The largest was a $35 million early-stage round in Mar 2024; the most recent was a $106 million Series B in Nov 2025.

Profluent investors

10 investors are on record for Profluent, including Insight Partners (New York), Spark Capital, Jeff Dean and Altimeter Capital Management. By type, the record holds 4 venture capital firms, 1 family office and 1 private equity firm. The Series B in Nov 2025 drew 4 investors.

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Frequently asked about Profluent

How much has Profluent raised?
Profluent has raised $150.0M in total across 2 recorded funding rounds.
When was Profluent's last funding round?
Profluent's most recent recorded round was Early Stage VC (Series B) in Nov 2025, raising $106.0M.