Protego Biopharma

San Diego, CA · Founded 2011 · Privately Held (backing)

Developer of a small molecule therapeutics platform designed to reprogram protein folding for the treatment of various systemic amyloid diseases and protein misfolding diseases. Protego Biopharma is based in San Diego, CA and was founded in 2011. Its last reported valuation was $217 million in Mar 2025. It has raised $182 million across 3 recorded rounds; the latest was a $32.9 million early-stage round in Oct 2025.

Last reported valuation
$216.5M
Oct 2026
Priced at
—
Total raised
$182.1M
Last round
Early Stage VC
Oct 2025

Protego Biopharma key facts

as of Oct 2026
  • Developer of a small molecule therapeutics platform designed to reprogram protein folding for the treatment of various systemic amyloid diseases and protein misfolding diseases.
  • Protego Biopharma is valued at approximately $216.5M as of Oct 2026 (last reported valuation).
  • It has raised $182.1M across 3 recorded rounds; the latest was Early Stage VC ($32.9M) in Oct 2025.
  • Notable investors include Lightspeed Venture Partners, Johnson & Johnson Innovation - JLABS, Digitalis Ventures, Forbion, Novartis Venture Fund — 12 tracked in total.
  • Protego Biopharma has filed 3 Form Ds with the SEC since 2019, most recently Dec 2025 ($32.9M sold to 18 investors).
  • Status: Privately Held (backing).
Last reported valuation
LOW confidence
$216.5M

Protego Biopharma's last reported valuation, Mar 2025. Nothing priced has surfaced since.

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Protego Biopharma funding rounds

3 rounds
Oct 2025Early Stage VC$32.9MSEC filing▮
Oct 2021Later Stage VC$51.0MSEC filing▮
Dec 2019Seed Round$1.0MSEC filing▮

Protego Biopharma valuation

Protego Biopharma's last reported valuation was $217 million in Mar 2025. No priced round, secondary trade or fund mark has surfaced since.

How much has Protego Biopharma raised?

Protego Biopharma has raised $182 million in total; 3 of its rounds are on record, from 2019 on. The largest on record was a $51 million later-stage round in Oct 2021; the most recent was a $32.9 million early-stage round in Oct 2025.

Protego Biopharma has filed 3 Form Ds with the SEC since 2019, most recently in Dec 2025 ($32.9 million sold to 18 investors).

Protego Biopharma investors

12 investors are on record for Protego Biopharma, including Lightspeed Venture Partners, Johnson & Johnson Innovation - JLABS, Digitalis Ventures and Forbion. By type, the record holds 4 venture capital firms and 1 private equity firm. The early-stage round in Oct 2025 drew 18 investors.

About Protego Biopharma

Developer of a small molecule therapeutics platform designed to reprogram protein folding for the treatment of various systemic amyloid diseases and protein misfolding diseases. The company's drug discovery platform in order to address the protein misfolding problem, modulates the energetics of proteins using pharmacological chaperones and/or modulates the cellular folding, secretory and stress pathways, enabling doctors to obtain disease-modifying therapeutics.

Sector
Healthcare
HQ
San Diego, CA, United States
Founded
2011
Employees
22
Ownership
Privately Held (backing)

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